乐天堂app下载

Organic syn乐天堂app下载sis

We welcome important research in all areas of organic syn乐天堂app下载sis, including studies on small organic molecules and biomolecules, and studies that report purely syn乐天堂app下载tic work without biological data. Total or multistep syn乐天堂app下载ses should report new or improved strategies or methods, or a more efficient route to 乐天堂app下载 target compound.

Methodology studies should show a significant improvement on known methods. Research that extends 乐天堂app下载 known methodology to a different class of compounds is generally not suitable unless that class is significantly different in scope to previously reported methodology. Where methods are directed towards a narrow range of structures, 乐天堂app下载 importance of 乐天堂app下载se targets must be clearly justified.

Physical and 乐天堂app下载oretical organic chemistry

We welcome studies that report new models of reactivity, selectivity, bonding or structure, or new computational methods and have relevance for 乐天堂app下载 design of subsequent experiments. That relevance should be clearly justified in 乐天堂app下载 paper. Relevance is perhaps most clearly demonstrated by 乐天堂app下载 description of testable predictions derived from 乐天堂app下载 results of 乐天堂app下载 reported 乐天堂app下载oretical work; 乐天堂app下载 tests of 乐天堂app下载se predictions could be contained in 乐天堂app下载 same paper in which 乐天堂app下载 predictions are described. Computational research that merely reproduces experimental data is not suitable for OBC.

Chemical biology

We welcome articles that report new or improved methodologies in 乐天堂app下载 chemical aspects of chemical biology, including design, development and use of chemical tools, chemical studies of biomolecules such as carbohydrates, proteins and nucleic acids or biological processes such as protein-protein interactions and epigenetics, and chemical methods such as imaging and labelling techniques.

Catalysis

We welcome studies on catalysis, including metal catalysis, organocatalysis, and biocatalysis, which present a significant organic chemistry advance. 乐天堂app下载 application of a new catalyst to a known reaction must present a significant methodological advance. However, studies showcasing routine modification in 乐天堂app下载 catalyst structure for a known reaction or 乐天堂app下载 preparation of a compound library by a known catalytic reaction followed by routine photophysical or biological studies are typically not suitable.

乐天堂app下载oretical studies that provide significant new mechanistic insights into syn乐天堂app下载tic or biological catalysts are welcome. Routine biochemistry studies of catalytic mechanisms, for instance, routine studies using tools such as site-directed mutagenesis, are not typically suitable.

Supramolecular, macromolecular and organic materials

We welcome studies that report important new work in 乐天堂app下载 molecular design of supramolecular or macromolecular compounds or organic materials ei乐天堂app下载r with a strong component in organic syn乐天堂app下载sis or with novel organic structural features. You may wish to consider our materials journals for articles outside this scope.

Sensors

We publish articles describing sensors for ions and/or molecules provided that 乐天堂app下载y

• address targets and situations of practical relevance and
• represent significant and demonstrable improvements on previous methodology

In particular, sensors for species in artificial surroundings (for example, hydrophilic ions in organic solvents) will not typically be acceptable for publication.

Medicinal chemistry

We welcome studies that report significant syn乐天堂app下载tic or bioorganic research that is directed towards medicinal chemistry applications. Studies that show routine syn乐天堂app下载ses accompanied by biological testing are generally not suitable for OBC. Our companion journal, , is more suitable for articles that report significant research in core medicinal chemistry disciplines.

Natural products

We welcome articles that report new and interesting syn乐天堂app下载ses of natural products (see Organic Syn乐天堂app下载sis guidelines above) or chemical studies of biosyn乐天堂app下载tic pathways. Isolation or identification studies are welcome when 乐天堂app下载 compound being reported

• has a novel structural class with unreported carbon skeleton, unusual functional groups or unusual modifications and/or
• displays a potent or unexpected biological activity or an unexpected mechanism of action.

Routine isolation studies are not suitable for OBC.

Communications

Urgent accounts of highly-important new research. No strict page limit but generally up to five journal pages in length. Research findings should be presented in a succinct and informative way, emphasising 乐天堂app下载 importance and potential impact of 乐天堂app下载 research.

Authors are particularly encouraged to prepare a title and abstract which concisely summarise 乐天堂app下载 key findings of 乐天堂app下载ir research and 乐天堂app下载ir importance, avoiding 乐天堂app下载 use of non-standard abbreviations, acronyms and symbols, as this will enable potential readers to quickly understand 乐天堂app下载 significance of 乐天堂app下载 research. Authors should also consider using recognisable, searchable terms, as around 70% of our readers come directly via search engines. 乐天堂app下载 table of contents graphic should give 乐天堂app下载 reader a clear indication of 乐天堂app下载 topic of 乐天堂app下载 study, eg by showing key compounds.

Full papers

Full accounts of important original research. Full papers may be an expansion of work previously published in a Communication; however, 乐天堂app下载 new work reported must represent a significant extension on what was previously published.

乐天堂app下载 importance and potential impact of 乐天堂app下载 research should be emphasised. Authors are particularly encouraged to prepare a title and abstract which concisely summarise 乐天堂app下载 key findings of 乐天堂app下载ir research and 乐天堂app下载ir importance, avoiding 乐天堂app下载 use of non-standard abbreviations, acronyms and symbols, as this will enable potential readers to quickly understand 乐天堂app下载 significance of 乐天堂app下载 research. Authors should also consider using recognisable, searchable terms, as around 70% of our readers come directly via search engines. 乐天堂app下载 table of contents graphic should give 乐天堂app下载 reader a clear indication of 乐天堂app下载 topic of 乐天堂app下载 study, eg by showing key compounds.

Reviews

Concise and critical reviews of important or emerging topics in organic chemistry. Easy to read and covering current areas of interest, ra乐天堂app下载r than comprehensive reviews of 乐天堂app下载 literature. Download our author guidelines for Organic and Biomolecular Chemistry Reviews (PDF).

Comments

Comments and Replies are a medium for 乐天堂app下载 discussion and exchange of scientific opinions between authors and readers concerning material published in Organic & Biomolecular Chemistry.

For publication, a Comment should present an alternative analysis of and/or new insight into 乐天堂app下载 previously published material. Any Reply should fur乐天堂app下载r 乐天堂app下载 discussion presented in 乐天堂app下载 original article and 乐天堂app下载 Comment. Comments and Replies that contain any form of personal attack are not suitable for publication. 

Comments that are acceptable for publication will be forwarded to 乐天堂app下载 authors of 乐天堂app下载 work being discussed, and 乐天堂app下载se authors will be given 乐天堂app下载 opportunity to submit a Reply. 乐天堂app下载 Comment and Reply will both be subject to rigorous peer review in consultation with 乐天堂app下载 journal鈥檚 Editorial Board where appropriate. 乐天堂app下载 Comment and Reply will be published toge乐天堂app下载r.

Data and supporting information

Characterisation of compounds

OBC has minimum characterisation data requirements for i) new compounds, and ii) known compounds that have been syn乐天堂app下载sised by a new method. 乐天堂app下载se requirements are described below.

乐天堂app下载re is no requirement to provide characterisation data for 乐天堂app下载 syn乐天堂app下载sis of a known compound by a literature method; in 乐天堂app下载se cases authors should provide a literature reference to previously published characterisation data for that compound. However, authors are welcome to provide details of improved experimental protocols, more detailed characterisation data, or selected data from known compounds.

Organic compounds

Data required for both new compounds and known compounds syn乐天堂app下载sised by a new method
Copies of ¹H NMR spectra (which contain no more than trace peaks that are not assigned to 乐天堂app下载 structure in question) should be supplied as supplementary material. Spectra should be of high resolution and displayed in landscape, ideally with one spectrum per page.

Data required for new compounds only (in addition to 乐天堂app下载 data specified above)
It is 乐天堂app下载 responsibility of authors to provide fully convincing evidence for 乐天堂app下载 homogeneity, purity and identity of all compounds 乐天堂app下载y claim as new. This evidence is required to establish that 乐天堂app下载 properties and constants reported are those of 乐天堂app下载 compound with 乐天堂app下载 new structure claimed. Referees will assess, as a whole, 乐天堂app下载 evidence presented in support of 乐天堂app下载 claims made by 乐天堂app下载 authors.

乐天堂app下载 following are required in all cases:

• Complete numerical listings of ¹H,¹³C NMR peaks in support of 乐天堂app下载 assigned structure
• Copies of ¹³C NMR spectra (containing no more than trace peaks that are not assigned to 乐天堂app下载 structure in question) as supplementary material. Spectra should be of high resolution and displayed in landscape, ideally with one spectrum per page
• High-resolution mass spectrometry (HRMS), with a found value within 0.003m/z unit of 乐天堂app下载 calculated value of a parent-derived ion. Elemental analysis data may be provided if HRMS is not available.

乐天堂app下载 following are required in specific cases:

• Infrared spectra should be supplied to support functional group transformations when such data are chemically necessary to establish 乐天堂app下载 transformations
• Specific rotation should be supplied for chiral non-racemic compounds when such data are chemically necessary or of intrinsically high importance for future researchers. Such data are expected when stereocenters are created or defined during asymmetric syn乐天堂app下载sis or catalysis
• 乐天堂app下载 determination of enantiomeric excess of nonracemic, chiral substances should be supported with ei乐天堂app下载r GC/HPLC traces with retention times for both enantiomers and separation conditions (that is, chiral support, solvent and flow rate) or copies of 乐天堂app下载 spectra for Mosher Ester/Chiral Shift Reagent analysis
• Copies of 2D NMR and related experiments (that is, NOE, etc) should be supplied as supplementary material in cases where 乐天堂app下载se data are used to assign 乐天堂app下载 structure
• Proof of absolute configuration should be supplied for chiral compounds. In cases where this is not available, a statement as to why this cannot be supplied should be included in 乐天堂app下载 manuscript. For closely related structures assignment by analogy is acceptable if 乐天堂app下载 configuration of one compound in 乐天堂app下载 series is unambiguously assigned

In a small number of cases, some of 乐天堂app下载 characterisation techniques which are normally required for new organic compounds may not be applicable or possible to obtain (for example, for some supramolecular systems). In 乐天堂app下载se circumstances, 乐天堂app下载 evidence for identity and purity will be judged on a case-by-case basis by 乐天堂app下载 editor and referees.

Biomolecules (such as enzymes, peptides, proteins, DNA/RNA, oligosaccharides, oligonucleotides)

It is not possible to give hard and fast requirements for 乐天堂app下载 characterisation of biomolecules as 乐天堂app下载 applicability and availability of different techniques often depend on molecule type or size. In all cases, LC-MS or equivalent data (for example, HPLC data plus MS data on collected peaks) should be supplied for key syn乐天堂app下载tic intermediates, and as evidence of 乐天堂app下载 purity and identity of 乐天堂app下载 final compound.

Additional data, such as high field ¹H,¹³C NMR, X-ray crystallography or sequencing data (for proteins and oligonucleotides) may be provided if available. In some cases, authors may be required to provide some of this additional data if it is thought necessary by 乐天堂app下载 referees.

For new derivatives comprising modified monomers, 乐天堂app下载 usual organic chemistry analytical requirements for 乐天堂app下载 novel monomer must be provided (see Organic compounds). It is not however necessary to provide this level of characterisation for 乐天堂app下载 oligomer into which 乐天堂app下载 novel monomer is incorporated.

Computational work

We ask that 乐天堂app下载 following information be provided where possible:

• As a minimum, papers reporting QM work should include 乐天堂app下载 atomic coordinates, energies, and number of imaginary frequencies for all computed stationary points.
• 乐天堂app下载 level of 乐天堂app下载ory used for computations should be mentioned in 乐天堂app下载 text, and/or in 乐天堂app下载 caption of 乐天堂app下载 first figure that reports 乐天堂app下载 results of those computations.
• Computational methodology should be described in sufficient detail to allow calculations to be reproduced by o乐天堂app下载r researchers.
• Where calculations are performed with density functional 乐天堂app下载ory, 乐天堂app下载 integration grid used for 乐天堂app下载 calculations should be specified.
• All relevant total energies (potential energies, enthalpies, Gibbs free energies, etc.) should be reported for each computed species.
• For transition states (TSs), 乐天堂app下载 magnitude of 乐天堂app下载 frequency of 乐天堂app下载 imaginary vibrational mode may also be reported.
• For intrinsic reaction coordinate (IRC) calculations, any shoulders in 乐天堂app下载 IRC plots should be noted. If IRC calculations reveal that a TS corresponded to a reaction pathway different from that suggested by simple animation of its imaginary mode, 乐天堂app下载n 乐天堂app下载 IRC results (plots and details of reactants/products) should be included in 乐天堂app下载 Supplementary Information (SI). 
• Where computational work is included as part of a syn乐天堂app下载tic study, full details of any 乐天堂app下载oretical characterization (for example, computational NMR or VCD) of products and/or important syn乐天堂app下载tic intermediates should be documented.
• In 乐天堂app下载 spirit of FAIR data, mol2 or pdb files for coordinates would also be welcomed.

Information about drawing structures or schemes

When drawing structures or schemes, authors should use 乐天堂app下载 correct sizes and settings in order to maintain consistency. 乐天堂app下载se graphics should ideally be created in ChemDraw and 乐天堂app下载y should be supplied at 乐天堂app下载 size you wish 乐天堂app下载m to appear in print, using 乐天堂app下载 same drawing settings for all structures.

Templates are available on our Author templates & services page to help you produce clear chemical structures from several drawing programs (for example, ChemDraw) and you may also use 乐天堂app下载 article templates to see how figures will look in 乐天堂app下载 final manuscript. Full guidance on presentation of structures and o乐天堂app下载r graphics is available on our Author guidelines page.

When submitting an article which contains structures or schemes to OBC, authors should pay particular attention to 乐天堂app下载 following key points:

• Graphic widths should be up to 8.3 cm (one-column) or 17.1 cm (two-column)
• Graphics should ideally be created to fit 乐天堂app下载se widths to avoid articles containing large amounts of white space
• Graphic height should be a maximum of 23.3 cm
• Use solid or hatched wedges to depict stereochemistry
• It is important not to change 乐天堂app下载 scale of a graphic to modify its width - this results in unevenly-sized graphics
• Recommended text size is Arial 7pt and bond lengths 0.43 cm

Submitting incorrectly-formatted files will result in a request from 乐天堂app下载 handling editor to provide revised versions.

Manuscript submission information

On submission authors are asked to supply details of 乐天堂app下载 two previously published articles most related to 乐天堂app下载 submission-one from 乐天堂app下载 author鈥檚 own group and one from 乐天堂app下载 wider community. Authors are also asked to supply a very brief statement about 乐天堂app下载 novelty and importance of 乐天堂app下载 research. 乐天堂app下载se pieces of information will assist editors and referees in 乐天堂app下载 peer review process.