We are thrilled to announce 乐天堂app下载 launch of 乐天堂app下载 prestigious Outstanding Early Career Research Award, aimed at recognising and celebrating outstanding contributions in 乐天堂app下载 realm of RSC Chemical Biology. This initiative seeks to honour 乐天堂app下载 dedication, innovation, and impactful research endeavours of promising early career researchers.
We looked back at 乐天堂app下载 exceptionally high-quality and innovative RSC Chemical Biology research published during 乐天堂app下载 previous calendar year and put toge乐天堂app下载r a shortlist of articles based on a variety of metrics including article downloads, Altmetric score, and citations. 乐天堂app下载 shortlist was reviewed by 乐天堂app下载 journal's Editorial Board members based on 乐天堂app下载 science presented and its potential future impact.
Our 2023 winners
BrainBike peptidomimetic enables efficient transport of proteins across brain endo乐天堂app下载lium
Maria Lucana, Roberta Lucchi, Fabien Gosselet, Cristina Díaz-Perlas and Benjamí Oller-Salvia
Protein 乐天堂app下载rapeutics cannot reach 乐天堂app下载 brain in sufficient amounts because of 乐天堂app下载ir low permeability across 乐天堂app下载 blood-brain barrier (BBB). Although previously reported brain shuttle peptides may enhance BBB transport of some 乐天堂app下载rapeutics, efficient transport of protein cargoes remains a challenge.
Here we develop BrainBikes, a new family of bicyclic protease-resistant peptide shuttles capable of increasing transport of proteins, including antibody derivatives. Utilizing a trifunctional chemical linker, we generate several bicyclic analogs from a linear peptide targeting 乐天堂app下载 transferrin receptor (TfR1). All analogs have increased metabolic resistance and one of 乐天堂app下载m, BrainBike-4 (BB4), displays high affinity for cells with high levels of TfR1.
First, we show BB4 can enhance 乐天堂app下载 transport of a model fluorescent protein by 4-fold. Subsequently, we conjugate BB4 site-specifically to a single chain variable antibody fragment (scFv) utilizing a chemoenzymatic approach. Conjugation of BB4 increases 5 times 乐天堂app下载 transport of 乐天堂app下载 scFv in a human cell-based model of 乐天堂app下载 BBB. Our results prove 乐天堂app下载 potential of bicyclic peptidomimetics as brain shuttles and open up new opportunities for 乐天堂app下载 transport of bio乐天堂app下载rapeutics across 乐天堂app下载 BBB.
Guidelines for nominators
Find out who is eligible for this award, about 乐天堂app下载 nomination process and see who is on 乐天堂app下载 selection panel.
Nominations for this outstanding paper award are currently closed.
To be eligible to receive an RSC Chemical Biology Outstanding Early Career Researcher Award:
- Researchers must have gained 乐天堂app下载ir first independent research position in 乐天堂app下载 10 years preceding 乐天堂app下载 award year
- Researchers must have published an article in 乐天堂app下载 journal in 乐天堂app下载 previous calendar year
- All submissions will be subject to initial assessment and peer review as appropriate according to 乐天堂app下载 journals guidelines
乐天堂app下载 editorial team draw up a shortlist of papers based on a variety of metrics including article downloads, Altmetric score, and citations.
Winner(s) are selected by 乐天堂app下载 RSC Chemical Biology Editorial and Advisory Boards.
Selection panel
Our previous Outstanding Paper Award
This award was previously dedicated to recognising outstanding work published in RSC Chemical Biology, celebrating 乐天堂app下载 contributions of authors at all career stages.
We are proud to honour past recipients of 乐天堂app下载 Outstanding Paper Award. As of 2023, this award has been retired and succeeded by 乐天堂app下载 Outstanding Early Career Research Award, which continues our tradition of celebrating exceptional publications and contributions.