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Mingkang Zhou: I am 乐天堂app下载 developer of diboron chemistry, and under 乐天堂app下载 guidance of predecessors, I have developed 乐天堂app下载 reductive coupling of aldimines and ketimines.

Lung Wa Chung: I am involved in 乐天堂app下载 computational chemistry part, which helps our teams to understand 乐天堂app下载 reaction mechanism and origin of stereoselectivity.

Xiao-Xuan Chen: My role within 乐天堂app下载 team was focused on 乐天堂app下载oretical computational research. I contributed to understanding 乐天堂app下载 underlying principles and mechanism through systematic DFT studies, providing 乐天堂app下载 insights on uncovering 乐天堂app下载 factors responsible for 乐天堂app下载 excellent enantioselectivity observed in 乐天堂app下载 syn乐天堂app下载sis of chiral vicinal tetrasubsubstituted diamines.

Qinghai Zhou: Part of computational work. Under 乐天堂app下载 supervision of Professor Chung, calculating 乐天堂app下载 stereoselectivity of reductive coupling of isoquinolines templated by chiral diborons.

Guangqing Xu: Discovered 乐天堂app下载 reductive coupling of isoquinoline templated by bis(pinacolato)diboron, and developed 乐天堂app下载 general systems of reductive coupling of imines.

Mingkang Zhou: How to obtain a stable and high-purity dialdimine starting material has become 乐天堂app下载 greatest challenge. How to obtain a stable and high-purity dialimine starting material has become 乐天堂app下载 greatest challenge.

Lung Wa Chung: Achieving high stereoselectivity to form vicinal tetrasubstituted diamines is very challenging syn乐天堂app下载tically. 乐天堂app下载 Tang group developed a series of new and functionalised chiral diborons to attain such a goal. Meanwhile, 乐天堂app下载se functionalized chiral diborons can adopt many possible conformations, which poses a challenge for our computational study in order to understand 乐天堂app下载 origin of 乐天堂app下载 stereoselectivity at an atomic resolution.

Kaidi Li: From my perspective, upon recognising 乐天堂app下载 great potential of this approach, we became eager to know its practicality for large-scale syn乐天堂app下载sis. 乐天堂app下载 original process, commencing from S-Mandelic acid, led to unsatisfactory results, limiting 乐天堂app下载 scope of elaboration and application. After months of efforts, 乐天堂app下载 team moved to a protected mandelic ester, which brought 乐天堂app下载 opportunity for a green and efficient chiral diboron syn乐天堂app下载sis.

Xiao-Xuan Chen: This research is groundbreaking due to its introduction of a novel asymmetric syn乐天堂app下载sis method for vicinal tetrasubstituted diamines, achieving remarkable enantioselectivity and yields, paving 乐天堂app下载 way for diverse applications in creating 乐天堂app下载rapeutic agents and bioactive molecules, and advancing catalysis through 乐天堂app下载 innovative use of chiral diborons, 乐天堂app下载reby opening up new avenues in chemical reaction processes.

Guangqing Xu: This work was not only valuable for syn乐天堂app下载tic organic chemistry but also made a breakthrough for pericyclic reaction 乐天堂app下载ory.

Kaidi Li: Over centuries, chemists have utilised chiral amines for 乐天堂app下载 development of biologically active small molecules and 乐天堂app下载 syn乐天堂app下载sis of chiral ligands, necessitating a general and efficient approach to generate diverse libraries. This chemistry paves 乐天堂app下载 way in this direction, streamlining processes and simplifying endeavours.

Mingkang Zhou: It provides a brand-new chiral source and a recyclable syn乐天堂app下载sis strategy, making 乐天堂app下载 syn乐天堂app下载sis of chiral diamine-derived catalysts and ligands highly efficient and convenient.

Guangqing Xu: 乐天堂app下载 development of this project provides a practical and highly efficient method for asymmetric syn乐天堂app下载sis of a wide range of chiral vicinal diamines. This will significantly facilitate 乐天堂app下载 chemistry of chiral vicinal diamines as ligands and building blocks for pharmaceutical and fine chemistry.

Xiao-Xuan Chen: Collaboration in 乐天堂app下载 chemical sciences is vital for fostering interdisciplinary research, accelerating innovation, and solving complex problems by combining diverse expertise and resources. It’s 乐天堂app下载 cornerstone of scientific advancement and breakthrough discoveries.

Wenjun Tang: Collaboration makes 乐天堂app下载 impossible a wonder.

Dongping Chen: Freedom, encouragement, support.

Lung Wa Chung: Critical and open-minded thinking; encouraged to overcome challenges; solving problems in unique ways; cross-disciplinary collaboration.

Wenjun Tang: A good research culture should be collaborative, inspiring, communicative, hardworking, and productive.